What is restless legs syndrome?
Restless legs syndrome (RLS) is a neurological sensorimotor disorder characterized by an irresistible urge to move the legs, typically accompanied by uncomfortable sensations — described as crawling, pulling, throbbing, aching, or itching deep within the legs. Symptoms begin or worsen during rest or inactivity, are worse in the evening and night, and are temporarily relieved by movement. RLS affects 5-10% of the US population and is significantly underdiagnosed.
Impact on sleep
RLS is one of the most common causes of chronic insomnia. The urge to move prevents sleep onset, and periodic limb movements during sleep (PLMS) — a related phenomenon — cause frequent arousals. Chronic sleep deprivation from RLS contributes to fatigue, mood disturbance, cognitive impairment, and cardiovascular risk.
Causes
Primary (idiopathic) RLS has a strong genetic component. Secondary RLS is associated with iron deficiency (even without anemia), pregnancy, kidney disease, peripheral neuropathy, and certain medications (antidepressants, antihistamines, antinausea drugs). Iron studies are always part of the initial evaluation.
Treatment
Iron supplementation corrects deficiency-related cases. Dopaminergic medications (pramipexole, ropinirole, rotigotine patch) provide significant relief but carry risk of augmentation (worsening over time). Alpha-2-delta ligands (gabapentin, pregabalin) are preferred for long-term management. Low-dose opioids are used in refractory cases.